Why Transplanted Insulin Cells Die

�New research can enhance survival of islets transplants and ameliorate treatment of type 1 diabetes.


Transplantation of insulin-producing cell islets, alleged islets of langerhans is an appealing strategy for treatment of type 1 diabetes. But it turns out that these are short-lived, and the procedure needs to be repeated.


Now researchers at Link�ping University and Uppsala University in Sweden hind end show that accumulation of protein aggregatess, amyloid, in the transplanted cells whitethorn be causation their death.


Until now it was not known wherefore this insulin production ceases. The discovery now beingness published in The New England Journal of Medicine may change the course of diabetes research.


Transplant attempts have been carried out for more than 30 years. Hundreds of patients have had healthy insulin-producing islets of Langerhans cured from the pancreas of donors. These transplants, which usually postulate the injection of prison cell islets into the liver, normally go well, and the patients initially don't have to take insulin. But inside a year or deuce years the insulin production will stop from the transplanted cells.


"We have studied this in mice, simply it has naturally been difficult to do so in mankind. Now we have had an chance to examine such transplants in an individual with type 1 diabetes," says Gunilla T. Westermark, helper professor of cell biology at Link�ping University.


In close to half of the cell islets examined, 43 percent, the researchers establish lumps of amyloid.


"We previously know that amyloid production is a symptom of stress that leads to cell death in type 2 diabetes. Perhaps the same thing happens in a transfer, when cells are open to great stress," says Gunilla T. Westermark.


Interestingly, there were quite a few unaffected cubicle islets unexpended in the liver. If we toilet prevent the production of amyloid at an early stage, these cells would be able to stay on to bring about insulin. One possible scheme is to create a drug; another would be to refine the methods used in transplants in order to reduce stress.


Vetenskapsradet (The Swedish Research Council)
http://www.vr.se



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Today in History

1848: The Oregon Territory was created.

1900: International forces, including U.S. Marines, entered Beijing to put depressed the Boxer Rebellion, which was aimed at purging China of foreign influence.

1908: Rioting erupted in Springfield, Ill., as a white rout, enraged that two black criminal suspects (one later convicted of murder, the other exculpated of rape) had been spirited away from the city clink by authorities, began mount black-owned homes and businesses on fire. At least two blacks and pentad whites were killed in the force. (The sidesplitter helped inspire the universe of the NAACP the following year.)

1945: President Truman announced that Japan had surrendered unconditionally, termination World War II.

1980: Workers went on strike at the Lenin Shipyard in Gdansk, Poland, in a job action that resulted in the creation of the Solidarity labor movement.

2003: A huge blackout hit the northeastern United States and part of Canada; 50 million people lost power.

Today's Birthdays

Author Russell Baker, 83. Rock singer David Crosby, 67. Comedian-actor Steve Martin, 63. Actor Antonio Fargas, 62. Actress Susan Saint James, 62. Author Danielle Steel, 61. Film composer James Horner, 55. Actress Marcia Gay Harden, 49. Former basketball player Earvin "Magic" Johnson, 49. Singer Sarah Brightman, 48. Actress Halle Berry, 42. Actress Catherine Bell, 40.

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Glastonbury 2008 weather forecast: two days to go

Today's (June 25) weather forecast for this weekend's (June 27-29) Glastonbury festival, according to forecast service Metcheck, predicts hardly any rain during the entire weekend.

According to the service it will be sunny at the festival all day on Friday, with only the tiniest splattering of rain in the afternoon and temperatures hitting 20 degrees celcius.

On Saturday the weather is predicted to be cloudier, although there should only be a tiny amount of rain, with temperatures similar to the previous day.

A similar forecast is given for Sunday, the final day of the festival, which should be less cloudy, slightly colder, but with hardly any chance of rain.

Keep up with all the action from Glastonbury this weekend (June 27-29) as it happens on NME.COM. For news, pictures and blogs keep checking the NME.COM's Glastonbury Festival page. Plus make sure you get next week's issue of NME � on UK newsstands from July 2 � for the ultimate Glastonbury review.

Anuvida and Nik Tyndall

   
Artist: Anuvida and Nik Tyndall

   Genre(s): 
Easy Listening
   

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Discography:


   
 Reiki Healing Hands

   Year: 1995   
Tracks: 5

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Juno star drops out of Rami horror movie

Actress Ellen Page has pulled out of Sam Raimi's new horror movie 'Drag Me To Hell'.
The 'Juno' star had agreed to play the lead role in the film, however scheduling conflicts have now forced her to withdraw.
Shooting was due to get underway on March 17 in a bid to wrap before the possible Screen Actors Guild strike on June 30, but was then delayed.
However, the new date clashed with Page's forthcoming roles in psychological thriller 'Peacock' and Drew Barrymore's directorial debut 'Whip It!'
A statement from producers Ghost House Pictures and financier Mandate Pictures, read: "We were racing to start production so that we could accommodate Ellen's schedule.
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WILLIE NELSON

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